![]() However, the exact molecular mechanism of Tubby has not been determined. Tubby mutations in mice (tubby mice) cause late-onset obesity and neurosensory deficits such as retinal degeneration and hearing loss. Promoter fusions revealed that the two axonemal dynein genes Dmdnah3 (CG17150) and Dmdnai2 (CG6053) are expressed in chordotonal neurons, including the auditory ones in the flys ear. While the imagery of the three different stimuli did not reveal univariate activation differences, using multivariate pattern classification, we were able to decode the imagined stimulus type from BA2. Pymetrozine and pyrifluquinazon disturbed Drosophila coordination and hearing by acting on chordotonal stretch receptor neurons. TRPM mechano-reception touch hairs NOMPC TRPN chordotonal neurons NAN TRPV IAV noci-, thermo-reception many sensory neurons pyrexia dTRPA3 CNS neurons. Author Summary Tubby is a member of the Tubby-like protein (TULP) family. ![]() Independent of the content, during tactile mental imagery we found activation of frontoparietal regions, supplemented with activation in the contralateral BA2 subregion of S1, replicating previous reports. The cilium has a 9 + 0 axoneme structure and is highly sub-compartmentalised, with proximal and distal zones. To this end, healthy volunteers ( n = 21) either perceived or imagined three types of vibrotactile stimuli (mental content) while fMRI data were acquired. The Drosophila chordotonal neuron cilium is the site of mechanosensory transduction. The Voltage-gated sodium channel in Drosophila, Para, localizes to dendrites as well as axons in mechanosensitive chordotonal neurons March 2023 DOI: 10.1101/2023. Using fMRI and multivariate pattern analysis, we investigate whether this recruitment of sensory regions also reflects content-specific activation (i.e., whether the activation in S1 is specific to the mental content participants imagined). ![]() The imagination of tactile stimulation has been shown to activate primary somatosensory cortex (S1) with a somatotopic specificity akin to that seen during the perception of tactile stimuli. ![]()
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